Host Ira Glass explains the premise of the show, and we hear what's actually going on inside five of these cars.
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Linnel Peterson drives the Number 66 bus in Chicago, on Chicago Avenue. She grew up just blocks from the route, still lives near the route, and says it's strange whenever she drives her car on Chicago Avenue these days.
Nick Hornby, author of High Fidelity and About a Boy, explains the travails of driving his autistic son to the park.
An '88 Grand Marquis that Senator Conrad Burns inherited from his mother; a New York taxicab whose driver, Jeff Perkins, tape-records his passengers to help pass the time; a 1980s-era BMW 5 series in which film producer Rob Levine had his first job as driver and assistant to movie producer Edgar Sherrick.
Ernest Castle and his best friend Clarence tool around the neighborhood where they grew up—the Chicago suburb of Hazelcrest—drinking and running into friends on a Sunday morning.
David Sedaris, author of Me Talk Pretty One Day, explains how the most important moments of your life can happen in a car...and you can miss them.
Kelly Keggers demonstrates how there are angels on the road in San Francisco.
Mike Paterniti talks about working on a teen ambulance corps, growing up in Connecticut.