Host Ira Glass interviews author Alain de Botton about why so many of us choose the wrong spouses. Botton is the author of the new novel The Course of Love.

Julia Lillis talks to Ira about the huge, romantic move she made after a break up, and how it was both crazy and worth doing.

Producer Miki Meek spent a week with a family in the midst of a difficult situation. A woman who got in a car accident and then was in a coma for 52 days, woke up having forgotten the last two years of her life — during which she'd divorced her husband.

Mark Oppenheimer reports on agunah in the Orthodox Jewish community. An agunah is a woman whose husband refuses to give her a divorce – in Hebrew it means "chained wife." If you're an Orthodox Jew, strictly following Jewish law, the only real way to get divorced is if your husband agrees to hand you a piece of paper called a get.

In July, Tig was diagnosed with cancer. A week later she went on stage on Los Angeles and did a now-legendary set about her string of misfortunes.

A man discovers that his wife is cheating on him, and turns for advice to someone he's sure will have his back: his lawyer in the separation proceedings. Unfortunately for him, this is the worst person he could be turning to for advice...because his wife is cheating with the lawyer.

Host Ira Glass speaks with musician Kristy Kruger about the unique way she dealt with a recent breakup.

Jeanne Darst was 16 when her parents split up. But it turned out they just weren't too skilled at the whole divorce thing.

Host Ira Glass talks with Lauren Waterman, who's in the middle of a break-up right now and grappling with totally contradictory feelings. She wants her boyfriend to call, but also—maybe a little bit—doesn't want him to call.

Jeffrey Brown wrote a comic novel called Clumsy, a beautiful and intimate account of his relationship with his ex-girlfriend. He talks with Ira about the relationship and why he chose to draw cartoons about it after it ended.

"Joyce, I don't need another Housekeeper." Producer Jonathan Goldstein talks with the man who placed this ad. Joyce is the woman who left him.

Audio artist Jay Allison and writer Dan Robb present an audio montage on the moment Robb's parents divorced.